Advanced NMR Methodologies for Drug Discovery: From Fragment Screening to Atomic-Resolution mAb Characterization

Nicola Salvi (Sanofi)

Amphithéâtre Boudier

The integration of advanced NMR methodologies into drug discovery pipelines provides a versatile toolkit for accelerating therapeutic development, spanning from early-stage target validation to the rigorous quality control of complex biologics. This work showcases a multi-faceted NMR framework that leverages 19F NMR-based Fragment-Based Screening (FBS) for robust ligandability assessment and moves into high-resolution structural investigations of monoclonal antibodies (mAbs).