The detection/analysis of an individual element in a complex dynamic mixture presents an actual challenge to link properties of a biological system to its chemical components. The complementary expertise of the teams drives the development of new biosensors relying on ultra-sensitive plasmonic particles,[i] nanoformulated EPR probes[ii] to image redox-active species in animals, persistent luminescent nanoprobes[iii] for tumor imaging or DNP to follow specific metabolites in biological media.[iv] Additionally, non-specific methods like chemical-nose sensors arrays[v] or unsupervised metabolomics[vi] combined with machine learning will establish new diagnostic technics.
[i] Braïk, M. et al, Nanophotonics 2023, 12, 2179-2188. (https://doi.org/10.1515/nanoph-2023-0121).
[ii] Babic, N. et al, Magnetochemistry 2019, 5, 13 (https://doi.org/10.3390/magnetochemistry5010013).
[iii] Maldiney, T. et al, Nat. Materials 2014, 418-426 (doi: 10.1038/NMAT3908).
[iv] Dos Santos, K. et al, Prog. Nucl. Magn. Res. Spectroscopy. 2024, 144-145, 15-39 (https://doi.org/10.1016/j.pnmrs.2024.05.003)
[v] Das Saha, N. et al, J. Am. Chem. Soc. 2022, 144, 14363-14379 (https://doi.org/10.1021/jacs.2c05969).
[vi] a) Bertho, G. et al, J. Proteome Res. 2022, 21, 1041-1051 (https://doi.org/10.1021/acs.jproteome.1c00914). b) Nothias L.-F. et al Nat. methods 2020, 17, 905–908 (https://doi.org/10.1038/s41592-020-0933-6).